کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1877758 | 1042239 | 2011 | 4 صفحه PDF | دانلود رایگان |
The purpose of this analysis was to assess the potential of BNCT, with l-boronophenylalanine (l-BPA), as first line radiotherapy for glioblastoma multiforme (GBM). The survival of patients with newly diagnosed GBM from a phase II BNCT study was compared with those from the two arms of a phase III study with conventional radiotherapy (RT) vs. RT plus concomitant and adjuvant medication with temozolomide (TMZ). A small subgroup, for which the methylation status of the O6-methylguanine–DNA methyltransferase (MGMT) DNA-repair gene was known, was also considered. The results indicated that the use of BNCT with BPA should be explored in a stratified randomized phase II trial in which patients with the unmethylated MGMT DNA-repair gene are offered BNCT vs. RT plus TMZ.
Journal: Applied Radiation and Isotopes - Volume 69, Issue 12, December 2011, Pages 1737–1740