Radiation dosimetry estimates of [18F]-fluoroacetate based on biodistribution data of rats

We estimated the dosimetry of [18F]fluoroacetate (FAC) with the method established by MIRD based on biodistribution data of rats. We selected some important organs and computed their residence time, their absorbed doses and effective dose with the (%IDOrgan) human data using OLINDA/EXM 1.1 program. We observed the highest absorbed doses in the heart wall (0.025 mGy/MBq) and the lowest in skin (0.0079 mGy/MBq). The total mean absorbed doses and the effective doses were 0.011 mGy/MBq and 0.014 mSv/MBq, respectively. A 370-MBq injection of FAC leads to an estimated effective dose of 5.2 mSv. The potential radiation risk associated with FAC/PET imaging is well within the accepted limits.

Graphical AbstractFigure optionsDownload as PowerPoint slideHighlights
► We demonstrate a proper model to estimate the absorbed dose and effective dose of normal human.
► Dosimetry of [18F]-Fluoroacetate was estimated in human based on biodistribution of rats.
► A 370 MBq injection of [18F]-Fluoroacetate leads to an estimated effective dose of 5.2 mSv.