کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1879201 | 1532121 | 2013 | 7 صفحه PDF | دانلود رایگان |
Click chemistry has been widely applied in drug development including radiopharmaceuticals and has shown great advantages. Here we reported a novel strategy for rapid preparation of multiple 18F labeled PET probes in one pot using the ‘Click Reaction’ of Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes and organic azides (CuAAC). Preliminary results showed its high efficiency and potential for speeding up the preclinical screening of PET probes.
► With click labeling method, multiple PET probes can be labeled in one pot with high efficiency.
► Under proper HPLC conditions, multiple probes can be separated with high radiochemical purities and chemical purities.
► This strategy if combined with high throughout screening, the discovery of PET probes may be accelerated.
Journal: Applied Radiation and Isotopes - Volume 75, May 2013, Pages 64–70