کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1879501 | 1042573 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biodistribution of 34mCl-labeled 2-chloro-2-deoxy-d-glucose: A major impurity in [18F]FDG injection
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
No-carrier-added 2-[34mCl]chloro-2-deoxy-d-glucose ([34mCl]ClDG) was prepared via nucleophilic displacement reaction of 1, 3, 4, 6-tetra-O-acetyl-2-trifluoromethansulfonyl mannose with K[34mCl]Cl/kryptofix 222 complex using 34mCl− produced via the natS(α, 2n) nuclear reactions. The synthesis time from enrichment of [34mCl]Cl− was approximately 45 min and the radiochemical yield was 79.6±6.7% (n=3) with decay correction. Animal PET studies showed that the behavior of [34mCl]ClDG was quite different from that of [18F]FDG. [34mCl]ClDG did not accumulate in any organ and was excreted as [34mCl]ClDG.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 66, Issue 12, December 2008, Pages 1905–1909
Journal: Applied Radiation and Isotopes - Volume 66, Issue 12, December 2008, Pages 1905–1909
نویسندگان
Toshimitsu Fukumura, Makoto Takei, Kazutoshi Suzuki,