Tritiation of imipramine and pseudo irreversible analogues 3-Cyanoimipramine and 2-Nitroimipramine at high specific activity

Methods are presented to synthesize and characterize [N-methyl-3H] imipramine 3, [N-methyl-3H] 3-cyanoimipramine 6 and [N-methyl-3H] 2-nitroimipramine 9.