کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1891392 1533530 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans
ترجمه فارسی عنوان
تأثیر تابش گاما بر ژل شدن مسهل های گرمایشی از جنس گلوکز
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
چکیده انگلیسی


• Influence of γ-irradiation on a partially degalactosylated xyloglucan is investigated.
• Molecular weight reduction is observed in the investigated dose range.
• Modification of the temperature-induced mesoscopic gelation kinetics is evidenced.

Thermoresponsive degalactosylated xyloglucans have been already proposed as in situ gelling scaffolds for tissue engineering, due to their reversible macroscopic thermal gelation at body temperature and biodegradability. The highly branched, hydroxyl group-rich molecular structure renders xyloglucans interesting raw materials also in the form of micro/nanoparticles for application as nanoscalar drug delivery devices in cosmetic and pharmaceutical formulations. Owing to their natural source, xyloglucans show high average molecular weight, broad molecular weight distribution and poor water solubility, as large and compact aggregates usually form via inter-molecular hydrogen bonding. 60Co γ-irradiation has been here applied to reduce the molecular weight. The aqueous solutions of irradiated xyloglucan were characterized by dynamic light scattering measurements and gel filtration chromatography. The aggregation kinetics at 37 °C were studied by dynamic light scattering measurements to confirm the temperature-responsive behavior of this polymer even when dispersed in water at low concentration after γ-irradiation. Irradiation dose–molecular properties relationship has been sought.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiation Physics and Chemistry - Volume 94, January 2014, Pages 245–248
نویسندگان
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