کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1899204 1533996 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stirring a fluid at low Reynolds numbers: Hydrodynamic collective effects of active proteins in biological cells
ترجمه فارسی عنوان
مخلوط کردن یک مایع در تعداد رینولدز پایین: اثرات جمعی هیدرودینامیکی پروتئین فعال در سلول های بیولوژیکی
کلمات کلیدی
موتورهای مولکولی؛ ماشین آلات پروتئین؛ آنزیم ها؛ نفوذ؛ رانش؛ حمل درون سلولی
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات ریاضیات کاربردی
چکیده انگلیسی


• Stirring of fluids at low Reynolds numbers by a population of active force dipoles is considered.
• Advection of passive particles in the resulting fluctuating fluid flows is discussed.
• Diffusion enhancement and drift of the particles due to such advection are investigated.
• Application of the results to problems of diffusion in biological cells is made.

Most of the proteins in the cell, including not only molecular motors and machines, but also enzymes, are active. When ATP or other substrates are supplied, these macromolecules cyclically change their conformations. Therefore, they mechanically stir the cytoplasm and nucleoplasm, so that non-thermal fluctuating flows are produced. As we have recently shown (Mikhailov and Kapral, 2015), stochastic advection by such flows might lead to substantial diffusion enhancement of particles inside a living cell. Additionally, when gradients in the concentrations of active particles or in the ATP/substrate supply are present, chemotaxis-like drift should take place. Here, the motion of passive tracers with various sizes in a mixture of different kinds of active proteins is analyzed. Moreover, effects of hydrodynamic interactions on the motion of active proteins are explored. Theoretical results are compared with available experimental data for ATP-dependent diffusion of natural and microinjected particles in biological cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica D: Nonlinear Phenomena - Volumes 318–319, 1 April 2016, Pages 100–104
نویسندگان
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