Dysregulation of human Toll-like receptor function in aging

Studies addressing immunosenescence in the immune system have expanded to focus on the innate as well as the adaptive responses. In particular, aging results in alterations in the function of Toll-like receptors (TLRs), the first described pattern recognition receptor family of the innate immune system. Recent studies have begun to elucidate the consequences of aging on TLR function in human cohorts and add to existing findings performed in animal models. In general, these studies show that human TLR function is impaired in the context of aging, and in addition there is evidence for inappropriate persistence of TLR activation in specific systems. These findings are consistent with an overarching theme of age-associated dysregulation of TLR signaling that likely contributes to the increased morbidity and mortality from infectious diseases found in geriatric patients.

Research highlights
► Dysregulation of Toll-like receptor function occurs in aging humans.
► Adjustment for potential confounding factors is critical in human aging studies.
► Both impaired and inappropriate persistence of TLR function occur in aging humans.
► Transcriptional and post-transcriptional mechanisms contribute to TLR dysregulation.