کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1902410 | 1045744 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Circadian clocks and antiaging: Do non-aging microalgae like Euglena reveal anything?
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Microalgae that divide symmetrically in all aspects do not age. While the evolutionary reason for this is obvious, little attention has been paid to the mechanistic explanations. A great deal of study involving many research fields would be needed to explain the mechanisms if we suppose that the immortality results from a lifelong sufficiency of defense from stress or from an essential part of counteracting age-accompanied damage accumulation. Additionally, little is known about the relationships between homeostasis and circadian clocks in antiaging, although each of these has been studied separately. Here, we present a conceptual generalization of those relationships, as suggested by evidence from non-aging microalgae, mainly Euglena. The circadian gating of mitosis and circadian temporal coordination may respectively reduce radiation- and disharmony-induced stress in which homeostasis cannot be involved, whereas circadian resistance rhythms may greatly help homeostatic defense from radiation- and metabolism-induced stress. We also briefly sketch mammalian aging research to compare the current status of knowledge with that of algal antiaging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 9, Issue 2, April 2010, Pages 91-100
Journal: Ageing Research Reviews - Volume 9, Issue 2, April 2010, Pages 91-100
نویسندگان
Ken Goto, Chalinda K. Beneragama,