Association of Connexin37 C1019T with myocardial infarction and coronary artery disease: a meta-analysis

• The association of CX37 C1019 with MI and CAD was investigated by meta-analysis.
• Cx37 C1019T is a risk factor for MI.
• Cx37 C1019T is a protective factor for CAD.

BackgroundSeveral studies have reported that Connexin37 (Cx37) gene C1019T polymorphism is associated with myocardial infarction (MI) and coronary artery disease (CAD). However, the results remain contradictory.Methods and resultsPubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. A total of 3498 MI cases and 3986 controls, as well as 1808 CAD cases and 1197 controls were enrolled in this meta-analysis. For MI, the overall ORs and 95% CIs of 1019T were 1.04, 0.95–1.15; and 1.02, 0.85–1.22 in dominant and recessive models, respectively. For CAD, the overall ORs and 95% CIs of 1019T were 0.61, 0.51–0.72; and 0.52, 0.43–0.62 in dominant and recessive models, respectively. No publication bias was found in this meta-analysis.ConclusionsThis meta-analysis showed that Cx37 C1019T was a risk factor for MI and a protective factor for CAD.