کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1906274 1534883 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice
چکیده انگلیسی


• Toc, but not CoQ, reversed age-related impairments in coordinated running.
• Both Toc and CoQ improved cognitive performance of aged mice
• Combination of Toc and CoQ may be more effective than either one alone.
• Toc + CoQ was effective at decreasing protein oxidation in brain regions.
• The beneficial effects of the antioxidants were brain domain specific.

The purpose of this study was to determine if intake of the antioxidants coenzyme Q10 (CoQ10) or α-tocopherol (Toc), either alone or in combination, could ameliorate cognitive and psychomotor impairments of aged mice, as well as reduce oxidative burden in tissues. For a period of 10 weeks, male C57BL/6J mice (3 or 18 months) were fed either a control diet, or one of three diets supplemented with Toc, CoQ10 or their combination, and were tested for cognitive and psychomotor functions. Old mice on the Toc or Toc/CoQ10 diets showed improved coordinated running performance. Mice on the diet containing Toc/CoQ10 demonstrated improved performance in the discriminated avoidance task. CoQ10 and Toc alone also resulted in improved performance, albeit to a lesser degree. Protein damage was decreased especially when the mice received Toc + CoQ10 combination. Overall, these results suggest that, Toc and CoQ supplementation can ameliorate age-related impairment and reduce protein oxidation. Moreover, concurrent supplementation of CoQ10 and Toc may be more effective than either antioxidant alone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 58, October 2014, Pages 208–218
نویسندگان
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