کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1906379 1046285 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The beneficial effect of myostatin deficiency on maximal muscle force and power is attenuated with age
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
The beneficial effect of myostatin deficiency on maximal muscle force and power is attenuated with age
چکیده انگلیسی

The prolonged effect of myostatin deficiency on muscle performance in knockout mice has as yet been only poorly investigated. We have demonstrated that absolute maximal force is increased in 6-month old female and male knockout mice and 2-year old female knockout mice as compared to age- and sex-matched wildtype mice. Similarly, absolute maximal power is increased by myostatin deficiency in 6-month old female and male knockout mice but not in 2-year old female knockout mice. The increases we observed were greater in 6-month old female than in male knockout mice and can primarily result from muscle hypertrophy. In contrast, fatigue resistance was decreased in 6-month old knockout mice of both sexes as compared to age- and sex-matched wildtype mice. Moreover, in contrast to 2-year old female wildtype mice, aging in 2-year old knockout mice reduced absolute maximal force and power of both sexes as compared to their younger counterparts, although muscle weight did not change. These age-related decreases were lower in 2-year old female than in 2-year old male knockout mice. Together these results suggest that the beneficial effect of myostatin deficiency on absolute maximal force and power is greater in young (versus old) mice and female (versus male) mice. Most of these effects of myostatin deficiency are related neither to changes in the concentration of myofibrillar proteins nor to the slow to fast fiber type transition.


► Myostatin deficiency increases both muscle absolute maximal force and power.
► These increases are greater in the female (versus male) and young female (versus old) mice.
► In contrast, myostatin deficiency markedly reduced fatigue resistance.
► Most of these myostatin effects are not related to changes in myofibrillar protein concentrations and fiber type composition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 48, Issue 2, February 2013, Pages 183–190
نویسندگان
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