کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907538 1046373 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age-dependent oxidation and aggregation of ZnT-1: A role for metal catalyzed oxidation?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Age-dependent oxidation and aggregation of ZnT-1: A role for metal catalyzed oxidation?
چکیده انگلیسی

Biological aging is associated with the oxidation and/or aggregation of a variety of proteins, which may contribute to the age-dependent loss of function. Protein modification can be caused by multiple chemical mechanisms, which may selectively target specific proteins. Here we show that the ZnT-1 isoform of the family of cation diffusion facilitators suffers age-dependent oxidation and covalent aggregation. Parallel in vitro experiments with a plasma membrane-rich fraction and recombinant ZnT-1 suggest that ZnT-1 aggregation may be caused by metal-catalyzed oxidation (MCO). The latter would be consistent with the known propensity of metal-binding proteins to suffer MCO.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 42, Issue 12, December 2007, Pages 1130–1136
نویسندگان
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