کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1908849 | 1046687 | 2012 | 17 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: HIV-1, reactive oxygen species, and vascular complications HIV-1, reactive oxygen species, and vascular complications](/preview/png/1908849.png)
Over 1 million people in the United States and 33 million individuals worldwide suffer from HIV/AIDS. Since its discovery, HIV/AIDS has been associated with an increased susceptibility to opportunistic infection due to immune dysfunction. Highly active antiretroviral therapies restore immune function and, as a result, people infected with HIV-1 are living longer. This improved survival of HIV-1 patients has revealed a previously unrecognized risk of developing vascular complications, such as atherosclerosis and pulmonary hypertension. The mechanisms underlying these HIV-associated vascular disorders are poorly understood. However, HIV-induced elevations in reactive oxygen species (ROS), including superoxide and hydrogen peroxide, may contribute to vascular disease development and progression by altering cell function and redox-sensitive signaling pathways. In this review, we summarize the clinical and experimental evidence demonstrating HIV- and HIV antiretroviral therapy-induced alterations in reactive oxygen species and how these effects are likely to contribute to vascular dysfunction and disease.
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► Vascular diseases are one of the most recognized non-AIDS events in HIV-1 patients.
► HIV-1 proteins and antiretrovirals have an impact on antioxidants and superoxide production.
► Increased reactive oxygen species (ROS) probably promote vascular disease.
► ROS also potentiate HIV-1 effects by altering viral replication and immune function.
► Targeting ROS sources or restoring antioxidants may reduce HIV vascular disease.
Journal: Free Radical Biology and Medicine - Volume 53, Issue 1, 1 July 2012, Pages 143–159