کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1909895 | 1046745 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2 Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2](/preview/png/1909895.png)
The J series of cyclopentenone prostaglandins (PGs) such as 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) are electrophilic lipid signaling mediators derived from the nonenzymatic dehydration of PGD2, a major product of the cyclooxygenase pathway. The biological actions of 15d-PGJ2 are attributed to its ability to form covalent adducts with thiol residues within specific signaling proteins, thus triggering redox-sensitive cell signaling pathways. One of the signaling pathways potently activated by 15d-PGJ2 is the Keap1–Nrf2–ARE system, which has a well-appreciated role in protecting cells from endogenous and exogenous stresses as well as anti-inflammatory effects. In this review, we give an overview of the mechanisms by which 15d-PGJ2 activates the Keap1–Nrf2–ARE system, focusing particularly on the role of Keap1 in sensing electrophilic stress. In addition, the Nrf2-dependent anti-inflammatory and cytoprotective effects of 15d-PGJ2 are discussed.
Journal: Free Radical Biology and Medicine - Volume 47, Issue 9, 1 November 2009, Pages 1310–1317