کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1910598 | 1046778 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro photostability and photoprotection studies of a novel 'multi-active' UV-absorber
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PBSBHTAIBNOMCUV-ATBATBARSMTT - MTTROS - ROSAntioxidant - آنتی اکسیدانEthylhexyl methoxycinnamate - اتیل هگزیل متوقف سیناماتThiobarbituric acid - اسید تیوباربیتوریکUV-absorber - اشعه ماوراء بنفشphosphatidylcholine - فسفاتیدیل کولینFibroblasts - فیبروبلاست هاLiposomes - لیپوزومPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریNitroxide - نیتروکسیدbutylated hydroxytoluene - هیدروکسی تورولین باتلاقیSunscreen - کرم ضد آفتابReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro photostability and photoprotection studies of a novel 'multi-active' UV-absorber In vitro photostability and photoprotection studies of a novel 'multi-active' UV-absorber](/preview/png/1910598.png)
چکیده انگلیسی
This paper reports on the synthesis and properties of a new UV-absorber (OC-NO) based on the most popular UV filter worldwide, ethylhexyl methoxycinnamate (OMC) in which the methoxy group has been replaced with a pyrrolidine nitroxide bearing antioxidant activity. This sunscreen active has therefore both UV-absorbing and antioxidant properties which could ideally address both the UV-B and UV-A skin photo-damage. For broad-spectrum coverage, the combinations of OC-NO with two commonly used UV-A absorbers (BMDBM and DHHB) were also studied. The results obtained reveal that OC-NO: (a) is as photostable as OMC after UV-A exposure; (b) acts as free radical scavenger as demonstrated by EPR and chemical studies; (c) reduces UV-A and UV-A+BMDBM induced lipid peroxidation in liposomes and cells, measured as reduced TBARS levels and increased C11-BODIPY red fluorescence, respectively; (d) has comparable antioxidant activity to that of vitamin E and BHT commonly used in skin care formulations; (e) is non-cytotoxic to human skin fibroblasts as assessed with the MTT assay when exposed to increasing doses of UV-A; and (f) OC-NO+DHHB is a promising, photostable broad spectrum UV-filter combination that concomitantly reduces UV-induced free radical damage. These results suggest that nitroxide/antioxidant-based UV-absorbers may pave the way for the utilization of 'multi-active' ingredients in sunscreens thereby reducing the number of ingredients in these formulations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 45, Issue 3, 1 August 2008, Pages 345-354
Journal: Free Radical Biology and Medicine - Volume 45, Issue 3, 1 August 2008, Pages 345-354
نویسندگان
E. Venditti, T. Spadoni, L. Tiano, P. Astolfi, L. Greci, G.P. Littarru, E. Damiani,