کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1910822 1046788 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels
چکیده انگلیسی

Oxidative stress can cause methionine oxidation that has been implicated in various proteins malfunctions, if not adequately reduced by the methionine sulfoxide reductase system. Recent evidence has found oxidized methionine residues in neurodegenerative conditions. Previously, we have described elevated levels of brain pathologies and an abnormal walking pattern in the methionine sulfoxide reductase A knockout (MsrA-/-) mouse. Here we show that MsrA-/- mice have compromised complex task learning capabilities relative to wild-type mice. Likewise, MsrA-/- mice exhibit lower locomotor activity and altered gait that exacerbated with age. Furthermore, MsrA-/- mice were less responsive to amphetamine treatment. Consequently, brain dopamine levels were determined. Surprisingly, relative to wild-type mice, MsrA-/- brains contained significantly higher levels of dopamine up to 12 months of age, while lower levels of dopamine were observed at 16 months of age. Moreover, striatal regions of MsrA-/- mice showed an increase of dopamine release parallel to observed dopamine levels. Similarly, the expression pattern of tyrosine hydroxylase activating protein correlated with the age-dependent dopamine levels. Thus, it is suggested that dopamine regulation and signaling pathways are impaired in MsrA-/- mice, which may contribute to their abnormal behavior. These observations may be relevant to age-related neurological diseases associated with oxidative stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 45, Issue 2, 15 July 2008, Pages 193–200
نویسندگان
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