کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1911966 | 1046852 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carbonyl modification in rat liver histones: Decrease with age and increase by dietary restriction
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Carbonyl modification in rat liver histones: Decrease with age and increase by dietary restriction Carbonyl modification in rat liver histones: Decrease with age and increase by dietary restriction](/preview/png/1911966.png)
چکیده انگلیسی
We studied carbonylation, a form of oxidative modification of proteins, of histones in rat livers. Histones H1, H2B/H2A, and H3 were significantly carbonylated but the modification was almost undetectable in H4. Contrary to the generally accepted view of increased protein carbonylation with age, the modification of histones was significantly lower in old (30-month-old) than in young (5-month-old) animals. Dietary restriction of older animals for 2 months resulted in increase in carbonylation comparable to that at the young level. These findings may have physiological implications in chromatin structure/function in aging and beneficial effects of DR by influencing transcription, replication, and/or repair activities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 40, Issue 7, 1 April 2006, Pages 1179–1184
Journal: Free Radical Biology and Medicine - Volume 40, Issue 7, 1 April 2006, Pages 1179–1184
نویسندگان
Ramesh Sharma, Akihiro Nakamura, Ryoya Takahashi, Hideko Nakamoto, Sataro Goto,