کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919027 1047988 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes
چکیده انگلیسی

ObjectivesIntestinal bacterial metabolize the soy isoflavone daidzein to O-desmethylangolensin (O-DMA) or equol. Some individuals do not excrete O-DMA or equol after soy consumption, suggesting they do not harbor bacteria capable of producing these metabolites. The aim of this study was to evaluate bone mineral density (BMD) in relation to presence of these urinary metabolites.MethodsBMD, determined by whole-body dual X-ray absorptiometry scan, was age-adjusted and evaluated in relation to O-DMA-producer and equol-producer phenotypes in 92 postmenopausal women, aged 50–75 years. Women consumed supplemental soy foods (daidzein source) for 3 days and collected a first-void urine sample on the fourth day in order to determine metabolic phenotypes.ResultsIn O-DMA producers (n = 76) compared to O-DMA non-producers (n = 16), greater total, leg and head BMD (p < 0.05) were observed. Total BMD among the O-DMA producers (geometric mean = 1.04 g/cm2) was 6% greater than total BMD among the O-DMA non-producers (geometric mean = 0.98 g/cm2). Total and site-specific BMD did not differ between equol producers (n = 24) and non-producers (n = 68) (p > 0.05). In exploratory analyses, among regular soy consumers, spinal BMD was 20% lower among the equol producers than non-producers, whereas, among soy non-consumers, no such difference was observed (p-interaction < 0.05). Among equol producers, circulating estrone and free estradiol concentrations were inversely or not associated with total BMD, whereas, among equol non-producers, these hormones were positively associated (p-interaction < 0.05).ConclusionsOur results provide evidence that intestinal bacterial composition may influence BMD in postmenopausal women. Further studies characterizing associations of intestinal bacterial profiles with BMD are warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Maturitas - Volume 53, Issue 3, 20 February 2006, Pages 315–324
نویسندگان
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