Plant extracts for the treatment of menopausal women: Safe?

E2 and genistein share uterotropic and mammatropic effects in ovx rats. If occurring in postmenopausal women this may endanger these organs to develop malignancies. Serum LH levels were inhibited by E2 and the CR BNO 1055 extract whereas genistein had no estrogenic effect in the hypothalamus and it is therefore unlikely that genistein inhibits climacteric complaints.