کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919261 1535629 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases
چکیده انگلیسی

Reactive oxygen species (ROS), generated endogenously during respiration or exogenously by genotoxic agents, induce oxidized bases and single-strand breaks (SSBs) in DNA that are repaired via the base excision/SSB repair (BER/SSBR) pathway in both the nucleus and mitochondria. Tightly regulated BER/SSBR with multiple sub-pathways is highly complex, and is linked to the replication and transcription. The repair-initiating DNA glycosylases (DGs) or AP-endonuclease (APE1) control the sub-pathway by stably interacting with downstream proteins usually via their common interacting domain (CID). A nonconserved CID with disordered structure usually located at one of the termini includes the sequences for covalent modifications and/or organelle targeting. While the DGs are individually dispensable, the SSBR-initiating APE1 and polynucleotide kinase 3′ phosphatase (PNKP) are essential. BER/SSBR of mammalian nuclear and mitochondrial genomes share the same early enzymes. Accumulation of oxidative damage in nuclear and mitochondrial genomes has been implicated in aging and various neurological disorders. While defects in BER/SSBR proteins have been linked to hereditary neurodegenerative diseases, our recent studies implicated transition metal-induced inhibition of NEIL family DGs in sporadic diseases. This review focuses on the recent advances in repair of oxidatively damages in mammalian genomes and their linkage to aging and neurological disorders.


► This review focuses on the broad repair mechanisms for oxidative damage in mammalian nuclear and mitochondrial genomes.
► Multiple repair sub-pathways involving distinct repair complexes.
► Role of disordered terminal extensions and posttranslational modifications in the early BER proteins are summarized.
► The impact of BER/SSBR deficiency in central nervous system (CNS) on aging and neurodegenerative diseases is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 133, Issue 4, April 2012, Pages 157–168
نویسندگان
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