کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919566 1535664 2008 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA mismatch repair: Molecular mechanism, cancer, and ageing
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
DNA mismatch repair: Molecular mechanism, cancer, and ageing
چکیده انگلیسی

DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important cellular functions. In its role in post-replication repair, MMR safeguards the genome correcting base mispairs arising as a result of replication errors. Loss of MMR results in greatly increased rates of spontaneous mutation in organisms ranging from bacteria to humans. Mutations in MMR genes cause hereditary nonpolyposis colorectal cancer, and loss of MMR is associated with a significant fraction of sporadic cancers. Given its prominence in mutation avoidance and its ability to target a range of DNA lesions, MMR has been under investigation in studies of ageing mechanisms. This review summarizes what is known about the molecular details of the MMR pathway and the role of MMR proteins in cancer susceptibility and ageing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 129, Issues 7–8, July–August 2008, Pages 391–407
نویسندگان
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