کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919571 1535664 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HGPS and related premature aging disorders: From genomic identification to the first therapeutic approaches
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
HGPS and related premature aging disorders: From genomic identification to the first therapeutic approaches
چکیده انگلیسی

Progeroid syndromes are heritable human disorders displaying features that recall premature ageing. In these syndromes, premature aging is defined as “segmental” since only some of its features are accelerated. A number of cellular biological pathways have been linked to aging, including regulation of the insulin/growth hormone axis, pathways involving ROS metabolism, caloric restriction, and DNA repair. The number of identified genes associated with progeroid syndromes has increased in recent years, possibly shedding light as well on mechanisms underlying ageing in general. Among these, premature aging syndromes related to alterations of the LMNA gene have recently been identified. This review focuses on Hutchinson–Gilford Progeria syndrome and Restrictive Dermopathy, two well-characterized Lamin-associated premature aging syndromes, pointing out the current knowledge concerning their pathophysiology and the development of possible therapeutic approaches.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 129, Issues 7–8, July–August 2008, Pages 449–459
نویسندگان
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