کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919885 1535685 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans
چکیده انگلیسی

Several alterations in immune function and a concomitant progressive increase in pro-inflammatory status are the major characteristics of ageing process. Cytokines play a key role during ageing acting both in regulatory communication among cells and in effector activity during an immune response. The impact of age on intracellular Type 1 (IFN-γ and TNF-α) and Type 2 (IL-4) cytokines, after stimulation with PMA/ionomycin, was determined in three CD4+ T subsets, i.e. CD95−CD28+ (virgin), CD95+CD28+ (activated/memory), and CD95+CD28− (effector/memory) from 47 subjects aged between 21 and 99 years. The percentage of IFN-γ positive cells significantly decreased in virgin CD4+ subset both in old and nonagenarian subjects, as well as in activated/memory T cells from old in comparison with young subjects. The percentage of TNF-α positive cells significantly decreased in activated/memory CD4+ subset from old people. Regarding Type 2 cytokines, IL-4 positive cells significantly increased in activated/memory CD4+ subset from nonagenarians. On the whole our data indicate that: (1) different Type 1 and Type 2 cytokine-positive CD4+ T subsets are differently affected by ageing process; (2) activated/memory T cells appear to be the most affected subset; (3) a shift towards an increased role of Type 2 cytokines and a diminished role of Type 1 cytokines emerges with ageing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 127, Issue 6, June 2006, Pages 560–566
نویسندگان
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