کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919887 1535685 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T cell development, ageing and Interleukin-7
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
T cell development, ageing and Interleukin-7
چکیده انگلیسی

Interleukin-7 (IL-7) is a cytokine with a central role in the development and maintenance of the peripheral T cell pool. In the mouse, expression of the IL-7 gene in the thymus has been carefully followed from gestation onwards throughout the lifespan. One of the features of its expression in the thymus is that it changes with time, declining measurably as the animal ages. This reduction is associated with a decrease in thymic size, cellularity and output. Analysis of transgenic animals carrying either IL-7 or IL-7 receptor transgenes reveals that the intrathymic level of IL-7 has a critical effect on the production of T cells, and that this may not be a linear relationship. This is an important consideration for therapy involving treatment of old animals with IL-7 of which there are reports indicating some rejuvenation of the thymus following IL-7 treatment, which is never complete. The thymus does not appear to return to the size and cellularity seen in youth. Several possible scenarios could account for this, including the inability to maintain IL-7 within defined limits in the thymus during the therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 127, Issue 6, June 2006, Pages 572–578
نویسندگان
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