کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1919908 | 1535678 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Semantic distinctions between “normal” aging, “pathological” aging (or age-related disease) and “premature” aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 128, Issue 1, January 2007, Pages 58-63
Journal: Mechanisms of Ageing and Development - Volume 128, Issue 1, January 2007, Pages 58-63
نویسندگان
Marieke van de Ven, Jaan-Olle Andressoo, Valerie B. Holcomb, Paul Hasty, Yousin Suh, Harry van Steeg, George A. Garinis, Jan H.J. Hoeijmakers, James R. Mitchell,