کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1920008 1535689 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease
چکیده انگلیسی

Behavioural and psychological symptoms of dementia (BPSD) occur in 50–90% of Alzheimer's disease (AD) patients. Imbalance of different neurotransmitters (acetylcholine, dopamine, noradrenaline and serotonin), involvement of specific brain regions responsible for emotional activities (parahippocampal gyrus, dorsal raphe and locus coeruleus) and cortical hypometabolism have been proposed as neurobiological substrate of BPSD. Compared to with respect to the neurochemical component, the cholinergic dysfunction seems to play a major role in contributing to BPSD occurrence. This view is also supported by the findings of recent trials with cholinesterase inhibitors, showing that these drugs are effective in controlling and/or improving BPSD, independent on effects on cognitive dysfunction. On the site of psychotropic drugs, atypical or novel antipsychotics represent the reference drugs for treating BPSD, whereas classic antipsychotic drugs for their profile and the potential side effects should be avoided.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 127, Issue 2, February 2006, Pages 158–165
نویسندگان
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