کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1920012 | 1535689 | 2006 | 15 صفحه PDF | دانلود رایگان |
We provide an overview of synaptic pathology in dementia with Lewy bodies (DLB) and related neurodegenerative disorders that are characterised by intraneuronal accumulation of α-synuclein aggregates. The review addresses the clinico-neuropathological correlates of synaptic pathology in Lewy body disease, and concentrates on: altered α-synuclein metabolism, mechanisms leading to α-synuclein fibril formation (self-polymerisation, α-synuclein mutations and post-translational modifications) and how these influence the axonal transport and synaptic network in ageing and disease process. Understanding the mechanisms leading to intraneuronal α-synuclein accumulation are crucial for the development of novel therapies for treatment of Lewy body disease.
Journal: Mechanisms of Ageing and Development - Volume 127, Issue 2, February 2006, Pages 188–202