کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1923069 1535846 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response
ترجمه فارسی عنوان
وابستگی متقابل متابولیسم تتراپیرلرو، تولید استرس اکسیداتیو و پاسخ استرس اکسیداتیو مضر
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Tetrapyrroles are involved in light sensing and oxidative stress mitigation.
• Reactive oxygen species (ROS) can form upon light exposure of free tetrapyrroles.
• Tetrapyrrole homeostasis must be tightly regulated to avoid oxidative stress.
• ROS can result in cellular damage or oxidative stress signaling in cells.

Tetrapyrroles are involved in light harvesting and light perception, electron-transfer reactions, and as co-factors for key enzymes and sensory proteins. Under conditions in which cells exhibit stress-induced imbalances of photosynthetic reactions, or light absorption exceeds the ability of the cell to use photoexcitation energy in synthesis reactions, redox imbalance can occur in photosynthetic cells. Such conditions can lead to the generation of reactive oxygen species (ROS) associated with alterations in tetrapyrrole homeostasis. ROS accumulation can result in cellular damage and detrimental effects on organismal fitness, or ROS molecules can serve as signals to induce a protective or damage-mitigating oxidative stress signaling response in cells. Induced oxidative stress responses include tetrapyrrole-dependent and -independent mechanisms for mitigating ROS generation and/or accumulation. Thus, tetrapyrroles can be contributors to oxidative stress, but are also essential in the oxidative stress response to protect cells by contributing to detoxification of ROS. In this review, we highlight the interconnection and interdependence of tetrapyrrole metabolism with the occurrence of oxidative stress and protective oxidative stress signaling responses in photosynthetic organisms.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Redox Biology - Volume 4, April 2015, Pages 260–271
نویسندگان
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