Heme oxygenase-1 regulates postnatal lung repair after hyperoxia: Role of β-catenin/hnRNPK signaling

► HO-1KO has worsened lung structure after hyperoxia and in room air recovery. ► Protein synthesis is inhibited and cell cycle gene expression is dysregulated in the KO. ► In the WT neonatal lung, HO-1 protein localizes to the nucleus in hyperoxia. ► HO-1 interacts with hnRNPK in vitro and in vivo. ► This modulates protein synthesis and gene expression explaining lung abnormalities.