کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1924988 1536339 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Developmental pathways activated in melanocytes and melanoma
ترجمه فارسی عنوان
مسیرهای رشد فعال در ملانوسیت ها و ملانوم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Melanocyte development and melanoma progression share similarities.
• Developmental genes critical for melanocyte and melanoma development are described.
• Several genetic pathways are highlighted including Notch, Wnt, Endothelins and Sox.

Cutaneous malignant melanomas originate primarily within epidermal melanocytic cells. Melanoma cells share many characteristics with melanocyte precursors, suggesting that melanoma cells utilize the developmental programs of their normal counterpart for their own progression. The pigmentation system provides an advantageous model to assess survival pathway interactions in the melanocytic lineage, as genetic alterations controlling melanocyte development can be easily detectable by coat color phenotype that do not affect the viability of an animal. By integrating combinatorial gene knockout approaches, cell-based assays and immunohistochemical observations, recent studies have illustrated several genes and pathways that play important roles both in melanocyte specification and maintenance and in melanoma formation and progression. We are reviewing those genes and pathways to understand the connection between normal and cancerous development and to reveal therapeutic potential of targeting developmental pathways for melanoma therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 563, 1 December 2014, Pages 13–21
نویسندگان
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