Structure, mechanism, and dynamics of UDP-galactopyranose mutase

- UDP-galactopyranose mutase (UGM) catalyzes the formation of UDP-galactofuranose.
- UGM requires reduced flavin for activity.
- Nucleophilic attack by the flavin initiates ring contraction.
- Redox-mediated conformational changes are important for flavin activation.
- Closing of the active site flaps is modulated by substrate binding.