Paracrine regulation of neural stem cells in the subependymal zone

Stem cells maintain their self-renewal and multipotency capacities through a self-organizing network of transcription factors and intracellular pathways activated by extracellular signaling from the microenvironment or “niche” in which they reside in vivo. In the adult mammalian brain new neurons continue to be generated throughout life of the organisms and this lifelong process of neurogenesis is supported by a reservoir of neural stem cells in the germinal regions. The discovery of adult neurogenesis in the mammalian brain has sparked great interest in defining the conditions that guide neural stem cell (NSC) maintenance and differentiation into the great variety of neuronal and glial subtypes. Here we review current knowledge regarding the paracrine regulation provided by the components of the niche and its function, focusing on the main germinal region of the adult central nervous system (CNS), the subependymal zone (SEZ).

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► Neural stem cells (NSCs) reside in a specialized “niche” that supports neurogenesis.
► Vasculature regulate NSCs function by secretion of molecules in the niche.
► The choroid plexus-CSF system produces factors that promote NSC maintenance.
► Astrocytes participate in the creation of the niche.
► Brain damage enhances proliferation of vasculature and NSCs.