کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1925544 1536390 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vitamin D compounds and diabetic nephropathy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Vitamin D compounds and diabetic nephropathy
چکیده انگلیسی

Vitamin D therapies for renal disease have been used for over a half century and are likely to be utilized for many more years. Past roles have been to alter calcium and phosphorus metabolism to prevent or lessen bone disease and reduce PTH levels in dialysis patients and more recently, pre-dialysis patients. However, emerging evidence indicates new applications for vitamin D compounds are likely to exist for this patient population. In addition to the possible new targets in this therapeutic area, a popularly debated topic is the ideal form of vitamin D for use in renal disease. Because the vitamin D metabolism system is severely altered in kidney disease, a thorough understanding of the disease progression relative to the vitamin D signaling pathway is necessary. The current state of knowledge in this area with the primary focus on patients with diabetic nephropathy will be the scope of this review.


► Vitamin D therapies have a long history in renal disease.
► New therapeutic targets for vitamin D compounds in this disease likely exist.
► A better understanding of disease development relative to hits on the vitamin D system is needed.
► The best vitamin D treatment regimen requires further study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 523, Issue 1, 1 July 2012, Pages 87–94
نویسندگان
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