The role of a membrane-bound glutathione transferase in the peroxynitrite-induced mitochondrial permeability transition pore: Formation of a disulfide-linked protein complex

► Mitochondrial permeability transition (MPT) pore components have not been elucidated. ► Peroxynitrite-induced MPT pore involves mitochondrial glutathione transferase (mGST). ► MGST forms a disulfide-linked protein complex. ► The complex includes mGST, adenine nucleotide translocator and cyclophilin D. ► The disulfide-linked protein complex might function as MPT pores to the swelling.