Specific antioxidant selenoproteins are induced in the heart during hypertrophy

► We model myocardial hypertrophy using thyroid hormone and isoproteranol in mice. ► The relationship between oxidative stress and selenoprotein expression in hearts is investigated. ► H2O2 and caspase-3 activity are increased, but no apparent tissue damage or apoptosis. ► MsrB1(Sel R), GPx3, and GPx4 are increased. ► GPx1, Trxrd1, and Trxrd2 expression are not changed in heart.