Intestinal Na+/Ca2+ exchanger protein and gene expression are regulated by 1,25(OH)2D3 in vitamin D-deficient chicks

► Calcitriol normalizes the intestinal NCX activity diminished by vitamin D deficiency. ► Calcitriol enhances NCX activity through protein and gene expression. ► Short-lasting effects on NCX activity is mediated by PKA and PKC signaling pathways.