کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1925976 | 1536429 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Sterol metabolism and SREBP activation Sterol metabolism and SREBP activation](/preview/png/1925976.png)
Cholesterol is one of the major components of membrane lipids. Adjustment of the membrane cholesterol balance is, therefore, pivotal in the maintenance of cellular homeostasis. Cholesterol biosynthesis and uptake are tightly regulated at the transcriptional level through a negative feedback control. The transcription factor family known as sterol regulatory element-binding proteins (SREBPs) is in charge of this feedback control. In particular, SREBP-2 is activated in a cholesterol-dependent manner, and hence is deeply involved in regulation of the expression of genes closely related to cholesterol metabolism. Sterol metabolites, including cholesterol, 24,25-dihydrolanosterol and oxysterols, strongly participate in the regulation of sterol metabolism via binding to its particular proteins.
Journal: Archives of Biochemistry and Biophysics - Volume 501, Issue 2, 15 September 2010, Pages 177–181