کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1926018 | 1536431 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Glutathione transferases and development of new principles to overcome drug resistance Glutathione transferases and development of new principles to overcome drug resistance](/preview/png/1926018.png)
Chemoresistance is a multifactorial phenomenon and many studies clearly show that a coordinated expression of efflux transporter proteins and phase II conjugating enzymes in tumor cells is linked to the development of the multidrug resistance phenotype. In particular, the overexpression of glutathione S-transferases and efflux pumps in tumors may reduce the reactivity of various anticancer drugs. In recent years it has become evident that glutathione S-transferases are also involved in the control of apoptosis through the inhibition of the JNK signaling pathway. As such, the glutathione S-transferase superfamily has become the focus of extensive pharmaceutical research in attempt to generate more efficient anticancer agents. Here we present an overview of the GST inhibitors and the GST-activated pro-drugs utilized to date to overcome drug resistance.
Journal: Archives of Biochemistry and Biophysics - Volume 500, Issue 2, 15 August 2010, Pages 116–122