کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1926717 1536475 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents
چکیده انگلیسی

A new class of carbamylating agents based on the cyclosulfamide scaffold is reported. These compounds were found to be efficient time-dependent inhibitors of human neutrophil elastase (HNE). Exploitation of the three sites of diversity present in the cyclosulfamide scaffold yielded compounds which inhibited HNE but not proteinase 3 (PR 3) or bovine trypsin. The findings reported herein suggest that the introduction of appropriate recognition elements into the cyclosulfamide scaffold may lead to highly selective agents of potential value in the design of activity-based probes suitable for investigating proteases associated with the pathogenesis of chronic obstructive pulmonary disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 475, Issue 2, 15 July 2008, Pages 115–120
نویسندگان
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