کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1926794 | 1536476 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion](/preview/png/1926794.png)
چکیده انگلیسی
Slp1 is a putative Rab27 effector protein and implicated in intracellular membrane transport; however, the precise tissue distribution and function of Slp1 protein remain largely unknown. In this study we investigated the tissue distribution of Slp1 in mice and found that Slp1 is abundantly expressed in the pancreas, especially in the apical region of pancreatic acinar cells. Slp1 interacted with Rab27B in vivo and both proteins were co-localized on zymogen granules. Morphological analysis of fasted Slp1 knockout mice showed an increased number of zymogen granules in the pancreatic acinar cells, indicating that Slp1 is part of the machinery of amylase secretion by the exocrine pancreas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 475, Issue 1, 1 July 2008, Pages 87–92
Journal: Archives of Biochemistry and Biophysics - Volume 475, Issue 1, 1 July 2008, Pages 87–92
نویسندگان
Chika Saegusa, Eiko Kanno, Shigeyoshi Itohara, Mitsunori Fukuda,