کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1926950 1536491 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vasodilatation of sulfur dioxide derivatives and signal transduction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Vasodilatation of sulfur dioxide derivatives and signal transduction
چکیده انگلیسی

The vasodilatation of sulfur dioxide (SO2) derivatives on the rat thoracic aortic rings and its cell signal transduction pathway were studied. The levels of cAMP, cGMP, PGI2, TXA2 and activities of PKA and adenylyl cyclase (AC) in the rings exposed to SO2 derivatives were determined. The results indicated that SO2 derivatives could dose-dependently relax the isolated rat aorta rings with or without endothelium precontracted by NE, no difference was found between the rings with and without endothelium; Levels of cAMP, PGI2, AC activity and PKA activity in the aortic rings were significantly increased by the derivatives in a dose-related way; No change of cGMP and TXA2 levels in rings was observed; cAMP/cGMP and PGI2/TXA2 ratios were increased significantly by the SO2 derivatives. These results led to the conclusions that SO2 derivatives might cause the endothelium-independent vasorelaxation effect, and the vasorelaxation was mediated in partly by the signal transduction pathway of PGI2-AC-cAMP-PKA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 467, Issue 2, 15 November 2007, Pages 291–296
نویسندگان
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