کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1927224 | 1536507 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
K+-induced ion-exchanges trigger trypsin activation in pancreas acinar zymogen granules
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: K+-induced ion-exchanges trigger trypsin activation in pancreas acinar zymogen granules K+-induced ion-exchanges trigger trypsin activation in pancreas acinar zymogen granules](/preview/png/1927224.png)
چکیده انگلیسی
Trypsin premature activation has been thought to be a key event in the initiation phase of acute pancreatitis. Here we test a hypothesis that a sustained increase of cytosolic Ca2+ concentration ([Ca2+]C) can trigger K+ influx into pancreas acinar zymogen granules (ZGs) via a Ca2+-activated K+ channel (KCa), and this influx of K+ then mobilizes bound-Ca2+ by K+/Ca2+ ion-exchange to increase free Ca2+ concentration in the ZGs ([Ca2+]G) and release bound-H+ by K+/H+ ion-exchange to decrease the pH in ZGs (pHG). Both the increase of [Ca2+]G and the decrease of pHG will facilitate trypsinogen autoactivation and stabilize active trypsin inside ZGs that could lead to acute pancreatitis. The experimental results are consistent with our hypothesis, suggesting that K+ induced ion-exchanges play a critical role in the initiation of trypsin premature activation in ZGs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 459, Issue 2, 15 March 2007, Pages 256-263
Journal: Archives of Biochemistry and Biophysics - Volume 459, Issue 2, 15 March 2007, Pages 256-263
نویسندگان
Kai Yang, Yong-Xue Ding, Wei-Chun Chin,