کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1942254 | 1052598 | 2013 | 14 صفحه PDF | دانلود رایگان |

In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K+ (mKATP) channel. This review will address the involvement of complex II in each of these areas, with a focus on how complex II regulates or may be involved in the assembly of the mKATP. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.
► The role of complex II in assembly & regulation of the mKATP channel will be discussed.
► We propose a unifying hypothesis on how mKATP and complex II regulate bioenergetics.
► We also discuss the role of complex II and mKATP in disease pathology & protective signaling.
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1827, Issue 5, May 2013, Pages 598–611