کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1942254 1052598 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel
چکیده انگلیسی

In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K+ (mKATP) channel. This review will address the involvement of complex II in each of these areas, with a focus on how complex II regulates or may be involved in the assembly of the mKATP. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.


► The role of complex II in assembly & regulation of the mKATP channel will be discussed.
► We propose a unifying hypothesis on how mKATP and complex II regulate bioenergetics.
► We also discuss the role of complex II and mKATP in disease pathology & protective signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1827, Issue 5, May 2013, Pages 598–611
نویسندگان
, , , , ,