کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1943447 | 1052666 | 2007 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanism and energetics of proton translocation by the respiratory heme-copper oxidases
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mechanism and energetics of proton translocation by the respiratory heme-copper oxidases Mechanism and energetics of proton translocation by the respiratory heme-copper oxidases](/preview/png/1943447.png)
چکیده انگلیسی
Recent time-resolved optical and electrometric experiments have provided a sequence of events for the proton-translocating mechanism of cytochrome c oxidase. These data also set limits for the mechanistic, kinetic, and thermodynamic parameters of the proton pump, which are analysed here in some detail. The analysis yields limit values for the pK of the “pump site”, its modulation during the proton-pumping process, and suggests its identity in the structure. Special emphasis is made on side-reactions that may short-circuit the pump, and the means by which these may be avoided. We will also discuss the most prominent proton pumping mechanisms proposed to date in relation to these data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1767, Issue 10, October 2007, Pages 1200–1214
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1767, Issue 10, October 2007, Pages 1200–1214
نویسندگان
Mårten Wikström, Michael I. Verkhovsky,