کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1943657 1052678 2006 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Factors influencing the energetics of electron and proton transfers in proteins. What can be learned from calculations
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Factors influencing the energetics of electron and proton transfers in proteins. What can be learned from calculations
چکیده انگلیسی

A protein structure should provide the information needed to understand its observed properties. Significant progress has been made in developing accurate calculations of acid/base and oxidation/reduction reactions in proteins. Current methods and their strengths and weaknesses are discussed. The distribution and calculated ionization states in a survey of proteins is described, showing that a significant minority of acidic and basic residues are buried in the protein and that most of these remain ionized. The electrochemistry of heme and quinones are considered. Proton transfers in bacteriorhodopsin and coupled electron and proton transfers in photosynthetic reaction centers, 5-coordinate heme binding proteins and cytochrome c oxidase are highlighted as systems where calculations have provided insight into the reaction mechanism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1757, Issue 8, August 2006, Pages 942–968
نویسندگان
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