Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

• Extracellular ATP concentration is increased in the tumour microenvironment.
• ATP-gated P2X7 receptor expression changes in cancer cells compared to normal epithelial cells.
• Assessing P2X7-related activities is critical for understanding carcinogenesis.
• P2X7 agonists or antagonists for epithelial cancer treatment?

P2X7 is an intriguing ionotropic receptor for which the activation by extracellular ATP induces rapid inward cationic currents and intracellular signalling pathways associated with numerous physiological processes such as the induction of the inflammatory cascade, the survival and proliferation of cells. In contrast, long-term stimulation of P2X7 is generally associated with membrane permeabilisation and cell death. Recently, P2X7 has attracted great attention in the cancer field, and particularly in the neoplastic transformation and the progression of solid tumours. A growing number of studies were published; however they often appeared contradictory in their results and conclusions. As such, the involvement of P2X7 in the oncogenic process remains unclear so far. The present review aims to discuss the current knowledge and hypotheses on the involvement of the P2X7 receptor in the development and progression of solid tumours, and highlight the different aspects that require further clarification in order to decipher whether P2X7 could be considered as a cancer biomarker or as a target for pharmacological intervention. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

Figure optionsDownload high-quality image (197 K)Download as PowerPoint slide