کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1944153 1053187 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The minimalist architectures of viroporins and their therapeutic implications
ترجمه فارسی عنوان
معماری مینیمالیستی ویروپورین ها و پیامدهای درمانی آن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Provide an overview of the known architectures of viroporins
• Review of the minimalist structural solutions adopted by influenza H + channels and HCV p7 channel
• Discuss how structures explain the molecular mechanism of ion selectivity and transport
• Discuss how adamantane derivatives block M2 and p7 viroporins and mechanism of drug resistance

Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity. In the past five years, structures obtained by nuclear magnetic resonance (NMR), X-ray crystallography, and electron microscopy (EM) showed that viroporins often adopt minimalist architectures to achieve their functions. A number of small molecules have been identified to interfere with their channel activities and thereby inhibit viral infection, making viroporins potential drug targets for therapeutic intervention. The known architectures and inhibition mechanisms of viroporins differ significantly from each other, but some common principles are shared between them. This review article summarizes the recent developments in the structural investigation of viroporins and their inhibition by antiviral compounds. This article is part of a Special Issue entitled: Viral Membrane Proteins—Channels for Cellular Networking.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1838, Issue 4, April 2014, Pages 1058–1067
نویسندگان
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