کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1944165 1053187 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasticity and conformational equilibria of influenza fusion peptides in model lipid bilayers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Plasticity and conformational equilibria of influenza fusion peptides in model lipid bilayers
چکیده انگلیسی


• Conformational equilibria of influenza fusion peptides
• Coarse-grained model describing peptide insertion
• Modelling of trimeric assembly of fusion peptides

Membrane fusion is critical to eukaryotic cellular function and crucial to the entry of enveloped viruses such as influenza and human immunodeficiency virus. Influenza viral entry in the host cell is mediated by a 20–23 amino acid long sequence, called the fusion peptide. In the last years, possible structures for the fusion peptide and their implication in the membrane fusion initiation have been proposed; these ranging from an inverted V shaped α-helical structure to an α-helical hairpin, or to a complete α-helix. Here we develop a coarse grained approach to describe effectively the plasticity of the fusion peptide and the explored conformational states. We describe also a trimeric assembly for the fusion peptide and analyse the explored states in a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine model membrane. For the single fusion peptide systems the kink angle observed experimentally for the V shaped structure shows a strong correlation with the orientation of the fusion peptide within the lipid bilayer. The trimeric fusion peptide model also experiences different conformational states and represents a more realistic model for the anchoring mechanism of one influenza haemagglutinin molecule. This article is part of a Special Issue entitled: Viral Membrane Proteins — Channels for Cellular Networking.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1838, Issue 4, April 2014, Pages 1169–1179
نویسندگان
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