کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1944497 1053217 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transmembrane helix dimerization: Beyond the search for sequence motifs
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Transmembrane helix dimerization: Beyond the search for sequence motifs
چکیده انگلیسی

Studies of the dimerization of transmembrane (TM) helices have been ongoing for many years now, and have provided clues to the fundamental principles behind membrane protein (MP) folding. Our understanding of TM helix dimerization has been dominated by the idea that sequence motifs, simple recognizable amino acid sequences that drive lateral interaction, can be used to explain and predict the lateral interactions between TM helices in membrane proteins. But as more and more unique interacting helices are characterized, it is becoming clear that the sequence motif paradigm is incomplete. Experimental evidence suggests that the search for sequence motifs, as mediators of TM helix dimerization, cannot solve the membrane protein folding problem alone. Here we review the current understanding in the field, as it has evolved from the paradigm of sequence motifs into a view in which the interactions between TM helices are much more complex. This article is part of a Special Issue entitled: Membrane protein structure and function.


► Transmembrane helix dimerization studies shed light on membrane protein folding.
► Helix dimerization in membranes has been described within the sequence motif paradigm.
► The sequence motif paradigm in membrane protein folding is incomplete.
► The search for sequence motifs cannot solve the membrane protein folding problem.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1818, Issue 2, February 2012, Pages 183–193
نویسندگان
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